Save $120
Best
value
value
$69 $49 per bottle
On subscription: $44.10 a bottle, $264.60 a course, 10 percent off every course
Add to cartTotal: $294
Shipping on us
180-day guarantee
Any reason, empty bottles and all.
A letter from Dr Mark Weis, MD
Your knees are not wearing out. They are drying out.
The catch in your first step after sitting is the only part of it you can feel. A former Army physician on the Joint Jello your knees run on, why it has been thinning since you were thirty, and the farming village in Japan where it stays thick into the eighties.
Before I say anything, do one thing for me. My name is Dr Mark Weis, and I want you to stand up.
Stand up. Take three steps. Notice the first one.
That catch is what this letter is about, and it is not wear and tear.
Once you get going you are fine. It is the getting going. That is what this letter is about.
Nothing is stored; either answer simply continues the page.
If you are past sixty, that first step has a catch in it. The knee does not want to bend all the way. By the third step it eases, and by the twelfth you walk like yourself again, and that is exactly why nobody does anything about it.
Why it eases, and why that is the trap
Here is what the catch is. The fluid your knee moves in has been thinning about one percent a year since you were thirty; a journal measured it. Sit for an hour and that fluid goes still, and the thinner it is, the less there is between the two bones when you stand.
The twelve steps do not repair anything. They get what is left moving again, the way the wipers spread the last of the washer fluid across the glass, and tomorrow morning there is a little less to spread.
That is the arithmetic you are living in. Thirty years of it and more than a quarter of the fluid is gone, and it does not stop at sixty. The catch that takes three steps this year takes six in a few years’ time.
Where that road ends
Then it is not only mornings: it is the car after an hour, the stairs at the other end of the trip, the carpet with the grandchildren. The knee on the left below is where that road ends, and it is the average American knee at this age.
Now look at these two pictures. The same joint, two people of the same age. Can you see the difference?
What I promise you on this page
You will learn why that first step is the stiffest step of your day, from a study of more than 2,000 ancient skeletons. You will see what your joints are swimming in, and why the pill aisle that sold you glucosamine never mentioned it. And you will see the one thing a six-month study found that thickens it again.
Why an Army physician is writing to you
I am a physician, medical consultant and author. I did my medical school and postgraduate training at the University of Kansas School of Medicine, then worked as a primary care and emergency physician at a rural hospital in Kentucky, where I also served as Chief of Staff.
I then served my country as a civilian physician for the United States Army: at the Wounded Warrior Clinic at Fort Knox, as a General Medical Officer at Fort Riley, and as the lead primary care physician for the Army’s RESPECT-Mil screening program at Walter Reed Army Medical Center. Today I am the Medical Research Director at BioDynamix. I have watched what a stiff knee does to a strong person’s spirits, in soldiers and in everyday people, and that is why I am writing this.
Where I trained and served
BioDynamix is not endorsed by, sponsored by, or affiliated with these organizations.
★★★★★Ann Jagodzinski, WisconsinResults vary; the study section below describes the typical course.
I’d walk like an old lady.
“I’m in my car a lot for work, driving around and not moving much. I was having pain with my knees in the morning, getting out of bed. I was having a hard time getting in and out of the car, and I’d walk like an old lady.”
The mornings you already know
Out of bed, and the first steps are a shuffle, one hand on the dresser. The stairs, one at a time, hand on the rail, good leg first. Out of the car after an hour on the road, and you stand there a second before you trust the knee.
The garden in twenty-minute pieces. The jar lid you hand to someone else now. The grandkids on the carpet, and the little calculation you do about getting back up; somebody holds out a hand, and you take it and make a joke.
The pen that rolls under the desk and stays there. The doorknob you turn with two hands on a cold morning. The way you feel, some days, like the Tin Man in need of a squirt of oil.
The quiet thing nobody says out loud
The world gets a little smaller every year. The walk gets shorter. The trip gets planned around the stairs at the other end, and you say no to things, cheerfully, so nobody worries.
★★★★★Susana C. Lopez, 68Results vary; the study section below describes the typical course.
My children have been trusting me less and less to look after theirs.
“it was kinda obvious my children have been trusting me less and less to look after theirs.”
That is the moment most people decide to do something. Not the knee. The look on a daughter’s face.
How people say it when they call us
That last one is the one I respect most, and this letter answers it before it asks you for anything.
What you have already tried
You have tried things. The glucosamine, a year of it. The fish oil.
The cream that smells like a locker room. The pharmacy aisle at nine at night, reading the backs of bottles.
Some of it helped a little. Most of it did nothing you could point to.
Your doctor is a good doctor, and said what they all say. It is normal at your age; keep moving; maybe lose a few pounds. None of that was wrong, and none of it changed the first three steps.
In the next few screens I am going to explain exactly what happened inside your knee between step one and step twelve. Then I will show you the fluid it happened in, the study that measured it, and the one thing that thickens it. By the end you will be able to explain it to anyone in a sentence.
- what the aisle sold you, and why it could not have worked.
- what actually happened inside your knee between step one and step twelve.
- a village in Japan where people in their eighties squat and bend all day, and what their joints have that ours lose.
- the study that found how to get it back.
What the aisle sold you, and why it could not have worked
My friend Sarah, at the top of her stairs
Let me tell you about my friend Sarah. She is sixty-seven and lives in Arizona, and when she came to see me she was at rock bottom, in tears before she had finished her first sentence.
It started in her mid-forties, the way it starts for most people. She knelt on the floor to change her grandson’s diaper, and when she went to stand up her knees would not straighten for a few seconds.
By her early fifties, kneeling to play board games with the grandkids, her knees would crunch and grind like a sock full of broken glass. She hated the look of pity on those little faces when she grimaced getting up.
The two years that changed nothing
Her doctor said wear and tear. She took glucosamine every morning for two years, because the bottle said cartilage and her knees were cartilage, and it changed nothing. In the end she gave up the cake business that had been her identity, and that is the Sarah who sat in front of me.
I was shocked at the despair in an old friend, and as a physician I felt duty-bound to get to the bottom of it. Remember her, because her story does not end at the top of the stairs.
★★★★★Jennifer R. Capuano, 82Results vary; the study section below describes the typical course.
But I wasn’t ready to accept that.
“My doctor was one of those talking about wear and tear, and that there wasn’t much I could do about the pain in my hips and knees. ‘This is just what happens when we get old,’ he said, with a condescending look. But I wasn’t ready to accept that.”
Sarah was partly right, and so was her doctor. Joint discomfort does involve the cartilage. The cartilage does thin, and the swelling is real.
Everything she had been told was half of the truth. But the cartilage was never the root of it.
Add up what that half-truth cost
Two years of glucosamine at about forty-five dollars a month is more than a thousand dollars. Then the rubs, the pills, the co-pays, and a knee that was no different on the day she stopped than on the day she started.
Tap what you have bought. The total adds up here, with the arithmetic shown. Typical prices; yours may differ.
Tap the ones you have bought.
The first thing nobody told her
The National Institutes of Health spent more than twelve million dollars on the biggest test of those pills ever run. It followed 1,583 people with knee trouble for six months, and 572 of them for two full years, glucosamine and chondroitin against a sugar pill. Over the whole group, the supplements did no better than the sugar pill. 1
Study 1The biggest test of glucosamine ever run: no better than a sugar pill1,583 people with knee trouble for six months, 572 of them followed for two years; no advantage over placebo across the whole group.See the study
Read this first In a smaller group with moderate to severe pain, the combination showed a possible benefit that the trial was not designed to prove; the trial measured pain, not the joint fluid.
- The study
- The Glucosamine/Chondroitin Arthritis Intervention Trial (GAIT), funded by the National Institutes of Health
- Who, and how long
- 1,583 people with knee osteoarthritis for 24 weeks; 572 of them followed for two years
- What it found
- Across the whole group, glucosamine, chondroitin and the two together did no better than a placebo on knee pain.
- Reference
- Clegg DO et al., New England Journal of Medicine, 2006; Sawitzke AD et al., Annals of the Rheumatic Diseases, 2010
That study was published. The bottles stayed on the shelf. The makers kept selling them, and nobody on the aisle put a note beside the price.
The second thing, about the pills in the drawer
The anti-inflammatories she reached for on the bad days carry a warning the British Medical Journal put a number on in 2017, in a study of nearly 450,000 people. In the first week of taking them, the risk of a heart attack rose by as much as half. She did not know that, and almost nobody does. 2
Study 2Common anti-inflammatories: heart-attack risk up by as much as half in the first weekA study of nearly 450,000 people; the risk rose within the first week of use, at ordinary doses.See the study
Read this first An analysis of records, not a trial; the risk to any one person in a week is small, and it rose most with higher doses.
- The study
- An analysis of the health records of 446,763 people in Canada, Finland and the United Kingdom
- Who, and how long
- People who took ibuprofen, diclofenac, celecoxib or naproxen, compared with people who did not
- What it found
- The risk of a heart attack rose within the first week of use, by between about 20 and 50 percent depending on the drug and the dose.
- Reference
- Bally M et al., BMJ, 2017
And the rubs. They warm the skin. The skin is not where the trouble is.
Three things she did, and the one she never touched
So think about what she had actually done. She had fed the cartilage, and she had quieted the swelling. She had rubbed the outside.
Three things, and not one of them touched the fluid the cartilage lives in. Why would it be the fluid? Because of a study of very old knees.
What happened between your first step and your twelfth
Two thousand skeletons, and the old knees were the good ones
In 2017, two researchers at Harvard, Ian Wallace and Daniel Lieberman, measured the knees of more than two thousand skeletons. Some were from the last fifty years. Some were centuries old, and some were older than that.
If joints wore out like tires, the old skeletons should have had the worst knees. They had the best. The modern knees were the ones that had broken down, and the researchers wrote that it was not because of wear and tear. 3
Study 3The old skeletons had the better kneesMore than two thousand skeletons spanning centuries; worn knees were far more common in the modern ones, and age and weight did not explain the difference.See the study
Read this first The study shows the rise and rules out age and weight; it does not by itself say what the cause is.
- The study
- A survey of knee joints in skeletons from prehistoric, early-industrial and modern collections
- Who, and how long
- 2,576 skeletons, examined for the polished bone that worn knees leave
- What it found
- Worn knees were about twice as common in people who died after 1976 as in the early-industrial group, and age and body weight did not account for it.
- Reference
- Wallace IJ, Lieberman DE et al., Proceedings of the National Academy of Sciences, 2017
So here is what happened between your first step and your twelfth, and it is not wear and tear either.
Your cartilage is a sponge with no plumbing
The cartilage on the end of your thigh bone has no blood supply. None. Think of it as a sponge, thin and firm and alive, with no plumbing of its own.
A sponge drinks from whatever it sits in. Your cartilage sits in a thick, slippery fluid sealed inside the joint. I have called it Joint Jello for twenty years, because that is what it looks like when it is healthy.
Every step squeezes the sponge, and used fluid goes out. Lift your foot, the sponge springs back, and fresh Joint Jello soaks in. That squeeze and release is how your cartilage eats.
Now go back to standing up
sitting stillstep onesteps two and threestep twelve
You had been in the chair forty minutes. Nothing had moved.
Step one squeezed a sponge sitting in thin, still Joint Jello.
Step two moved some. Step three moved more.
By step twelve the sponge was drinking again. You did not get younger between step one and step twelve. You got the fluid moving.
Prove it to yourself. Stand up again, walk to the end of the room and back, sit for ten seconds, and stand once more.
Nothing in your knee healed in two minutes. The Joint Jello moved. That is the whole idea, in your own two legs.
Then the fluid is thin enough that one lap did not move much. Keep reading; the study below is about exactly that.
Nothing is stored; either answer simply continues the page.
Lubricate
like oil on a hinge.
Feed
the sponge has no other food.
Shield
it keeps the proteins that cause swelling away from the cartilage, like a bubble the cartilage sits inside.
A researcher at St George’s in London called this fluid the guardian of the joints. Remember the three jobs, because whatever fixes this has to answer all three. 4
Study 4“The guardian of the joints”The joint fluid lubricates, feeds the cartilage and keeps the inflammatory proteins off it; a researcher at St George’s, University of London, gave it that name.See the study
Read this first A description of the fluid’s roles; it does not test any product.
- The study
- A description of the joint fluid’s three jobs by a researcher at St George’s, University of London
- Who, and how long
- A review of what the fluid does, not a trial
- What it found
- The fluid lubricates, feeds the cartilage and keeps inflammatory proteins away from it, which is why it was called the guardian of the joints.
- Reference
- St George’s, University of London (the film’s citation; the paper to confirm at sign-off)
The part that is not your fault
What makes Joint Jello thick is a long molecule called hyaluronan. You may know it as hyaluronic acid, from skin creams. It holds the water in the fluid the way a sponge holds water.
From about age thirty, your body makes less of it. The journal Arthritis Research and Therapy put the loss at about one percent a year. At sixty, you have lost around thirty percent of your Joint Jello; at seventy, forty. 5
Study 5About one percent a year, from about age thirtyThe body’s output of hyaluronan, the molecule that thickens the joint fluid, falls by roughly one percent a year through adult life.See the study
Read this first An average across studies; the rate varies from person to person and joint to joint.
- The study
- Research on how the body’s production of hyaluronan changes with age
- Who, and how long
- Reviews and laboratory measurements across adult life
- What it found
- Production falls through adult life; the figure the film and the Letter use is about one percent a year from about age thirty.
- Reference
- Arthritis Research and Therapy (the paper to confirm at sign-off)
And you sit more than you did at thirty. Everybody does. So the pump runs less often, and what it pumps is thinner; the sponge is short-changed twice.
Grind, starve, swell
Thin Joint Jello cannot lubricate, so the joint grinds. It cannot feed, so the sponge starves. It cannot shield, so the swelling gets in.
Grind, starve, swell. That is the stiffness, the ache after the garden and the crunch on the stairs.
So the job was never to patch the cartilage. The job is to thicken the Joint Jello, and then to pump it.
A village where people in their eighties squat all day
Yuzurihara is a farming village a few hours from Tokyo. For most of the last century its people were studied because so many of them were still farming in their eighties and nineties. Squatting to plant, twisting to carry, bending to cut, for hours a day.
A village doctor, Toyosuke Komori, spent most of his working life there and wrote down what he saw: farmers in their eighties with the joints of people half their age. 6
Study 6Farmers in their eighties with the joints of people half their ageA village studied for most of a century for its long working lives; the village doctor’s records describe joints that stayed supple into the eighties and nineties.See the study
Read this first Observations of one village, not a controlled trial; diet, work, genes and the way of life all differ from ours.
- The study
- The records of the village doctor of Yuzurihara, Japan, and later reporting
- Who, and how long
- A farming village studied for most of the twentieth century for its long working lives
- What it found
- Farmers in their eighties and nineties with joints that stayed supple, planting and carrying for hours a day.
- Reference
- Dr Toyosuke Komori’s records (the source to confirm at sign-off)
Your joints are not like your tires, wearing out with every mile. If they were, these farmers would have the worst knees in Japan, and they have among the best. The second picture at the top of this page was a joint like theirs: thick Joint Jello at an age when most of us have lost a third of it.
Two dead ends before the answer
The first explanation was the diet. Their fields grew root vegetables rich in the starches the body uses to make hyaluronan, so the obvious answer was to eat the way they ate.
Dead end one, the diet
three or four purple sweet potatoes a day, every day, for months. I tried it on myself for six weeks; tired of sweet potatoes in a week, no thicker in the knees after six.
Dead end two, plain hyaluronic acid
a capsule of the bare molecule reaches the body, but slowly, and most of the early studies used it for skin, not knees. Most of what you swallow never reaches the Joint Jello at all. It is not what the Barcelona researchers built, and the difference is the next part.
I had patients who could not wait that long.
Barcelona built the fluid itself, and one study changed my mind
The studies behind this formula were published in
Then a group of researchers in Barcelona did something cleverer. Instead of plain hyaluronic acid, they built a matrix of it, with the other parts of natural Joint Jello folded in, and tested it in people with knee complaints.
Over the years that matrix, called Mobilee, has been through fourteen randomized, placebo-controlled, double-blind studies, which is the gold standard, and more than any other ingredient I have put in a joint formula. 7
Study 7Fourteen randomized, placebo-controlled, double-blind studiesThe hyaluronic acid matrix built in Barcelona has been tested in fourteen trials of the gold-standard design, more than any other ingredient in this formula.See the study
Read this first Many of the trials were supported by the ingredient’s maker and most were small.
- The study
- The body of trials behind the hyaluronic acid matrix called Mobilee
- Who, and how long
- Fourteen randomized, placebo-controlled, double-blind studies across adults with knee complaints
- What it found
- A consistent pattern of improved comfort and movement against placebo, which is more trials than any other ingredient in this formula has.
- Reference
- The published Mobilee trials (Bioiberica); the list is in the claims file
In the study I want you to see, adults took eighty milligrams a day for six months. Seventy people took it, and their own hyaluronan levels rose by a factor the paper puts at ten. 8
Study 8Eighty milligrams a day for six months: hyaluronan up tenfold, every month better than the lastSeventy adults, six months, 80 mg a day; the paper puts the rise in the body’s own hyaluronan at a factor of ten, and the improvement climbed month by month.See the study
Read this first Seventy people and the ingredient maker’s support; the measures were the body’s own hyaluronan and the participants’ reported comfort.
- The study
- The six-month Mobilee study
- Who, and how long
- Seventy adults, eighty milligrams a day for six months
- What it found
- Their own hyaluronan rose by a factor the paper puts at ten, and the improvement climbed month by month, with month six the best.
- Reference
- The six-month Mobilee study (journal and year to confirm at sign-off)
They did not level off. They kept improving.
And here is the part a six-month study can show that a six-week study cannot. They did not improve and then level off. They improved more each month than the month before: month one was the first change, and month six was the best month.
Thick Joint Jello takes time to build, and it kept building. That is why, when we get to what you can do about this, I am going to talk about six months and not thirty days.
Thicker Joint Jello, measured, and a curve that kept rising for six months. I had never seen that in one ingredient, and I have read a great many labels. So I took the papers to BioDynamix, a small company that makes formulas for people past fifty and asks one question of every ingredient before anything else: what dose did the study use?
Mobilee thickens the Joint Jello. That is the first of the three jobs, and the biggest. But the fluid does three things, and the second and third needed an answer too.
Five ingredients, four jobs
Rebuild
Mobilee, the hyaluronic acid matrix, 80 mg, the six-month study’s dose.
Guard
French maritime pine bark extract, 150 mg, the bark they found inside the knee.
Calm
boswellia, 100 mg at 65 percent boswellic acids, and ginger root, 200 mg.
Deliver
black pepper extract, 5 mg at 95 percent piperine, so the other four get through.
Rebuild and feed: the studied dose, and the part that is you
The failure was thin Joint Jello. The repair is Mobilee, eighty milligrams, the dose the six-month study used. Not a bigger number; the studied one.
The failure was a sponge sitting in still fluid, and part of that repair is you. Nothing feeds cartilage but motion, so whatever thickens the fluid still needs you to walk every day. If you will not walk, nothing in a capsule will do this for you; the other part is thicker Joint Jello, which carries more to the sponge every time you do move.
Guard: the bark they found inside the knee
The failure was swelling getting in while the fluid was thin. For that job I chose the bark of the French maritime pine, one hundred and fifty milligrams of its extract in every capsule, and I chose it for one study above the others.
In 2017, researchers in Germany gave an extract of that same bark to patients who were weeks away from a knee replacement, and then, when the surgeons opened the knee, they sampled the Joint Jello itself. The bark’s compounds were in it. Not in the blood: in the fluid, where the guarding happens. 9
Study 9The pine bark’s compounds were found in the joint fluid itselfPatients weeks from a knee replacement took the bark extract; when the surgeons opened the knee, its compounds were in the fluid, not only in the blood.See the study
Read this first A small study of one standardized extract (Pycnogenol); it shows the compounds reach the fluid, not an outcome over months.
- The study
- A study of patients about to have a knee replacement
- Who, and how long
- Thirty-three patients who took a standardized French maritime pine bark extract for three weeks before surgery
- What it found
- The bark’s compounds were found in the joint fluid itself when the surgeons opened the knee, and markers of inflammation in the fluid were lower.
- Reference
- Jessberger S et al., BMC Complementary and Alternative Medicine, 2017
Mobilee rebuilds the Joint Jello and the pine bark guards it. That would have been a good formula. It would not have been a complete one, because of what happens while the fluid is thin.
Calm: the second switch the pills never reach
While your Joint Jello was thinning, the swelling moved in, and swelling has two switches. The pills from the aisle reach one of them, which is why they work for an afternoon and why they carry that warning.
The second switch is an enzyme in the joint the common pills do not touch, and the resin of the frankincense tree, Boswellia serrata, is one of the few things that reaches it. There are a hundred milligrams of it in every capsule, standardized to sixty-five percent boswellic acids.
Study 10Ninety days of boswellia: better comfort, better movement, less of the cartilage-eating enzymeSeventy-five people with worn knees, ninety days, a hundred milligrams a day in one group; comfort and movement improved and the joint fluid carried less of the enzyme.See the study
Read this first The extract studied was enriched for one boswellic acid; the trial was supported by its maker and ran ninety days.
- The study
- A ninety-day trial of an enriched boswellia extract
- Who, and how long
- Seventy-five people with knee osteoarthritis; a hundred milligrams a day in one group, two hundred and fifty in another
- What it found
- Pain and function improved against placebo, and the joint fluid carried less of a cartilage-degrading enzyme afterwards.
- Reference
- Sengupta K et al., Arthritis Research and Therapy, 2008
Beside it, ginger root, two hundred milligrams, and not for the taste. Ginger reaches the first switch, gently, the way a warm cloth does, and I put it in for the days the knee flares, so the fluid can rebuild in peace.
Study 11Ginger: 63 in 100 reported less knee pain on standing, against 50 on the sugar pill261 people with sore knees, a ginger extract twice a day for six weeks; a modest difference and a real one.See the study
Read this first A modest difference, and more mild stomach upset in the ginger group.
- The study
- A six-week trial of a ginger extract
- Who, and how long
- 261 people with knee osteoarthritis, taking the extract twice a day
- What it found
- Sixty-three in a hundred reported less knee pain on standing, against fifty in a hundred on placebo.
- Reference
- Altman RD, Marcussen KC, Arthritis and Rheumatism, 2001
Deliver: the smallest ingredient, and the one most formulas skip
The last ingredient is the smallest and the easiest to leave out, which is why most formulas do. Five milligrams of black pepper extract, standardized to ninety-five percent piperine, and its one job is to hold the door open.
In small studies that same five milligrams raised the body’s uptake of beta-carotene by about sixty percent and of coenzyme Q10 by about a third. Without it you swallow more and keep less. With it, the other four get through. 12
Study 12Five milligrams of piperine raised uptake of beta-carotene by about sixty percentSmall human studies of the same piperine dose: beta-carotene absorption up by about sixty percent, coenzyme Q10 by about a third.See the study
Read this first The studies measured other nutrients, not the joint ingredients themselves; the principle is the same, the figure is theirs.
- The study
- Small human studies of piperine and nutrient uptake
- Who, and how long
- Healthy adults given five milligrams of piperine with a nutrient
- What it found
- Uptake of beta-carotene rose by about sixty percent and of coenzyme Q10 by about a third.
- Reference
- Badmaev V et al., 1999 and 2000
Take any one away and see what you lose
Mobilee alone rebuilds the fluid and leaves the swelling in it for weeks. Pine bark alone guards a fluid too thin to hold it. Boswellia and ginger alone calm the swelling and leave the sponge starving, which is the pill aisle’s mistake exactly, and leave out the pepper and you absorb less of all of it.
Mobilee
Hyaluronic acid in its natural matrix, from Barcelona
80 mg: rebuilds the Joint Jello, the six-month study’s dose
French maritime pine bark
The bark of a pine from the Atlantic coast of France
150 mg: guards the fluid from the inside
Boswellia
The dried resin of India’s frankincense tree
100 mg at 65 percent boswellic acids: calms the second switch
Ginger root
The kitchen root, dried and ground
200 mg: calms the first switch, gently
Black pepper
The dried fruit of the pepper vine; the heat in it is piperine
5 mg at 95 percent piperine: so the other four get through
That is the whole idea, and I want you to be able to say it back.
- Your joints are fed by motion, not blood, through the Joint Jello.
- The Joint Jello has been thinning one percent a year since you were thirty, which is why step one is the stiff one.
- Rebuild it, guard it, calm what got in, and walk to pump it.
Glucosamine fed the sponge and ignored the fluid
That is like changing the tires and fixing the radiator on your car and never adding engine oil. You can do it for two years, as my friend did, and the engine still grinds.
The formula I am about to show you is the engine oil.
Joint Genesis: the formula for the joint on the right
Today I am proud to introduce you to Joint Genesis.
- Manufactured in the USA from domestic and imported ingredients, in an FDA-inspected facility that follows current Good Manufacturing Practices
- More than 500,000 bottles sold
- Guaranteed for 180 days, any reason, empty bottles and all
- A person answers 800-589-4191
The order buttons are just above and just below. Go there whenever you are ready; I will keep going, because I want you to know what you are buying.
The label, line by line, and the job beside each line
- Hyaluronic acid matrix (Mobilee), 80 mg
- rebuilds the Joint Jello; the six-month study’s dose.
- Boswellia extract, 100 mg, standardized to 65 percent boswellic acids
- calms the swelling that moved in while the fluid was thin.
- Ginger root, 200 mg
- calms the first switch, gently, for the days the knee flares.
- French maritime pine bark extract, 150 mg
- guards the fluid from the inside.
- Black pepper extract, 5 mg, standardized to 95 percent piperine
- so the other four get through.
- One small capsule a day, with water, with breakfast. Thirty in a bottle, a month each. Every amount printed on the label; nothing hidden in a blend.
That is the formula in one breath. Rebuild it, guard it, calm what got in, and walk to pump it.
| What you tried | What it reached | The fluid the cartilage lives in |
|---|---|---|
| Glucosamine and chondroitin | The cartilage | Not touched |
| The anti-inflammatory pills | The swelling, for an afternoon, with the warning | Not touched |
| The rubs and creams | The skin | Not touched |
| Joint Genesis | The fluid itself, at the studied dose, plus the swelling and the absorption | Rebuilt, guarded, calmed, delivered |
The price and the three ways to order are just below. Here is what I arranged, and why.
Look at the two pictures from the top of the page again, the thin fluid and the thick. This is the formula for the one on the right.
Three people who had every reason to doubt it
★★★★★Chris Arthur, OregonResults vary; the study section above describes the typical course.
Now I can move better, I have less pain, I’m more flexible and I’m enjoying myself more.
“Two sets of x-rays two years apart showed bone-on-bone in both of my knees and I could barely walk. Now I can move better, I have less pain, I’m more flexible and I’m enjoying myself more. I feel confident that I can go for a walk. I can keep up with friends and take the dog round the block.”
★★★★★Gregory Haston, MissouriResults vary; the study section above describes the typical course.
I’m bending over nicely and can put on my shoes and socks.
“I could hardly bend over to put on my socks. Now I have much more stability and hardly any pain. I’m bending over nicely and can put on my shoes and socks and get where I’m going. I’m not worrying about limping or getting in and out of the car.”
★★★★★Joseph Basile, on camera in our last filmResults vary; the study section above describes the typical course.
I can now enjoy walks around the neighborhood without being in pain.
“Since taking Joint Genesis I can do chores around the house, outside, and in the garden. I can now enjoy walks around the neighborhood without being in pain.”
What to take from the label
Eighty milligrams of Mobilee is not a guess. It is the dose from the study that improved every month for six, and Joint Genesis gives you that dose, in that form, every morning.
What I arranged, and why
How it is made, and who makes it
Joint Genesis is manufactured for us in the United States, from domestic and imported ingredients, in a climate-controlled facility that follows current Good Manufacturing Practices and is inspected by the FDA, in small lots of about two thousand bottles.
1The ingredients arrive
Mobilee from Barcelona, pine bark from the French coast. Each is tested for purity and potency, and for toxins and contaminants, before it goes near a capsule.
2Weighed and blended in small lots
About two thousand bottles at a time, so no bottle sits in a warehouse for two years before it reaches you.
3One capsule, the day’s dose
Every amount printed on the label, nothing hidden in a blend, one small capsule with breakfast.
4Checked, then released
Current Good Manufacturing Practices in an FDA-inspected facility; a lot ships only when its tests are back.
Manufactured in the USA from domestic and imported ingredients, in an FDA-inspected cGMP facility; every lot tested for purity and potency.
Why BioDynamix exists, in a sentence
Most supplements are built backwards, from a price, and the dose is whatever fits. We build ours forwards, from the study, and the price is whatever that costs.
That is why there are five ingredients in this bottle and not fifteen. It is why you have read the word study from me more often than the word amazing, and why I told you who this is not for. And it is why the guarantee you are about to read covers empty bottles: a company that was not sure of its formula could not afford that promise, and we can, because of how it is made.
The calendar decides the pack
In the six-month study, month one was the first change people noticed. Month three was clearly better than month one. Month six was the best of all, because thick Joint Jello is built, not switched on.
- Weeks 1 to 4you may notice nothing. That is normal, and it is when the walking habit matters most.
- Weeks 5 to 8keep a note of your first three steps each morning.
- Weeks 9 to 12the end of the first course the research ran.
- The second coursewhere the study’s curve was steepest.
So I will tell you the truth about the first days. You will probably feel nothing in the first week; that is normal, and it is the week the walking matters most. Which is why I will not sell you one bottle and wish you luck.
One bottle, three, or the six the study ran
One bottle is a test. It is the right choice if you want to hold the label in your hand first, and it is there for you.
Three bottles is one round of the course, ninety days. By the end of it you are at the point in the study where the fluid was clearly thickening.
Six bottles is the course the study ran, and the second three months were where it got better fastest. It also ships once, so you never stand in week ten with an empty bottle and two weeks to wait. That is the six months I promised to explain: not a sales figure, the length of the study.
One more reason I lean to the six
It comes from the researchers, not from me. In a second Mobilee study, published in the Mediterranean Journal of Nutrition and Metabolism, the people taking it got stronger around the knee, and their stamina and power rose against the placebo group. 13
Study 13Stronger around the knee, more stamina and power than placeboA second Mobilee trial measured more than comfort: strength around the knee, stamina and power all rose against placebo.See the study
Read this first A manufacturer-supported trial; the measures were performance tests, not the fluid.
- The study
- A second Mobilee trial measuring physical performance
- Who, and how long
- Adults taking the matrix against placebo
- What it found
- Strength around the knee, stamina and power rose against the placebo group.
- Reference
- Mediterranean Journal of Nutrition and Metabolism (year to confirm at sign-off)
And when both trials ended and the participants stopped taking it, the improvements stopped too, and began to go into reverse. Joint Jello is built, and it thins again when you stop building it, so the people who do best treat this the way they treat a multivitamin: breakfast, capsule, walk. 14
Study 14When they stopped, the improvements stopped, and began to reverseIn both trials the gains held while the participants took it and started to go back once they stopped.See the study
Read this first A description of the follow-up period, not a separate trial.
- The study
- What happened after the Mobilee trials ended
- Who, and how long
- The participants of both trials, once they stopped taking it
- What it found
- The improvements stopped, and began to go into reverse.
- Reference
- The follow-up periods of the two Mobilee trials
What is it worth?
Most people I meet have already spent more than they think: a year of glucosamine that a 1,583-person study found no better than a sugar pill, the rubs, the pills with the warning. And at the far end of that road is a knee replacement.
Study 15Nine years after a knee replacement: less change than people hoped4,500 people followed for nine years; on average the operation had minimal effects on quality of life.See the study
Read this first An average; for people with severe symptoms the operation helped more, and the study is about who benefits, not against surgery.
- The study
- A nine-year follow-up of people with knee osteoarthritis, some of whom had a knee replacement
- Who, and how long
- 4,498 participants in the Osteoarthritis Initiative
- What it found
- On average the operation had minimal effects on quality of life; people with the worst function before surgery gained the most.
- Reference
- Ferket BS et al., BMJ, 2017
Two guides come with the three and the six
Included with the three and the six
Seventeen smoothies, a few minutes each, built around the foods that are good to your joints. Not homework: a nicer breakfast, and a good way to take the capsule.
A step-by-step guide to the simple habits that keep joints working at any age, done at home. It pairs with the capsule the way the daily walk does.
Both are digital and come with every order of three or six bottles.
The price, and the three ways to order
Through this letter, one bottle is sixty-nine dollars. Three bottles are two hundred and seven dollars, sixty-nine a bottle, with the shipping on us and the two guides. And the six-month course is two hundred and ninety-four dollars, which is forty-nine a bottle, about a dollar sixty a day, a hundred and twenty dollars saved against six single bottles, with the shipping on us.
Shipping on us
$69 per bottle
On subscription: $62.10 a bottle, $186.30 a course, 10 percent off every course
Add to cartTotal: $207
Shipping on us
180-day guarantee
Any reason, empty bottles and all.
$69 per bottle
On subscription: $62.10 a bottle, $62.10 a course, 10 percent off every course
Add to cartTotal: $69
Shipping at cost
180-day guarantee
Any reason, empty bottles and all.
Included on the three and the six: two digital guides, shown as their covers beside the packs. Included, not free.
Each pack has its own button, with the guarantee’s line under it.
Subscription, optional
- Your next course ships before this one runs out, so you never stand in week ten with an empty bottle.
- Ten percent off every course after this one, delivered every three or six months to match your pack.
- Nothing is charged today for it; the first charge is the day the next course ships, and you get an email a week before.
- Cancel any time with one call to 800-589-4191 or one click in that email. No questions.
The terms: the plan matches the pack you choose today; prices as shown on this page less ten percent; cancel before the reminder email’s date to skip a shipment; the 180-day guarantee covers every course.
Guaranteed for 180 days, any reason, empty bottles and all. Call 800-589-4191 and the desk refunds you.
Questions? Ask the desk, or call 800-589-4191; a person answers.
You will not be enrolled in anything you did not choose.
- Manufactured in the USA from domestic and imported ingredients, in an FDA-inspected facility that follows current Good Manufacturing Practices
- More than 500,000 bottles sold
- Guaranteed for 180 days, any reason, empty bottles and all
- A person answers 800-589-4191
What most people choose, and why
Two in every three new customers choose the six, and more than eight in ten choose the three or the six. Those are our own numbers for the year to the end of September. The second round is where people find out whether it stays in their routine, and most of them want it on the shelf before the first round ends.
★★★★★Patricia Bass, Virginia, partway through her courseResults vary; the study section above describes the typical course.
It’s not as often and it’s not as intense.
“I am really noticing a difference. The pain is decreasing. It’s not as often and it’s not as intense. And it makes me feel like it’s going to keep getting better.”
★★★★★Mary Mazur, Michigan, in an email with the subject line “Month 3 update”Results vary; the study section above describes the typical course.
My power walking is much smoother and I’ve improved my speed.
“My power walking is much smoother and I’ve improved my speed. I can exercise without feeling as though I’m stiff or I’m hurting afterwards. And we’ve had bad weather, we’ve had snow, all kinds of weather changes. Normally that would be a trigger but I’ve not experienced any since I started.”
That is the curve the study drew, in two people’s own words: better in month one, better still in month three.
The thing I am asked about most
We make Joint Genesis in small lots. The Mobilee comes from Barcelona and the pine bark from the Atlantic coast of France, and both are made to order. The latest lot of two thousand bottles reached our warehouse on the thirteenth of October, and the line under the pack table shows how many of them are on the shelf as you read this.
When a lot runs out there is a gap of some weeks, and the page says so. That is not a sales trick. It is the reason the page sometimes says sold out, and it is why I would rather you had the six on your shelf than three.
I am not asking you to decide today. I am asking you to take the six months the study took, and if your mornings have not changed, to call the number on the bottle and let us refund you, empty bottles and all.
My promise, in full
The 180-day promise
Here is the guarantee in full, because you have been burned before. Every package of Joint Genesis is covered for one hundred and eighty days from the day it arrives. Any reason. Even if every bottle is empty.
You call 800-589-4191 or email support@biodynamix.co, the desk confirms it on the spot, and the refund goes back to the card you paid with; most banks show it within a few business days. One length, one promise, every pack, and it is the same promise on every bottle BioDynamix makes. Choose the six and the guarantee covers all six.
Questions? Ask the desk, or call 800-589-4191; a person answers.
Think of it the way I do, as a deposit. You put the money down, you run the six months, and if you are not glad you did, you take the deposit back. The only thing you cannot get back is the six months, which is why I would start today rather than in the spring.
Four more people, for the doubts I hear most
★★★★★Sara Minter, 50Results vary; the study section above describes the typical course.
My knees don’t hurt anymore.
“My knees don’t hurt anymore, I have more mobility, and it just revives my whole body. This really has made a difference in my life.”
★★★★★Niueperiti Lesatele, 69Results vary; the study section above describes the typical course.
Before, I had to hold the side walking upstairs. Now I can just walk.
“Before I had to hold the side walking upstairs. But now I can just walk! My joints are far better now. So I’ve been walking a lot, and standing alone. I’m so grateful.”
★★★★★Marcos Wessolossky, Florida, in an email with the subject line “Big change!”Results vary; the study section above describes the typical course.
I know I can be there for my family now.
“Before Joint Genesis I was really scared about what might happen if I’m not able to go to work, make money, and provide for my family. It’s a huge difference now. I know I can be there for my family now, go to work and do everything I need to do.”
★★★★★Luz Florez, WashingtonResults vary; the study section above describes the typical course.
My pain on a scale of one to ten was an eight, but now I can say it’s almost disappeared.
“Before Joint Genesis I had a lot of pain and stiffness in my finger joints. My pain on a scale of one to ten was an eight, but now I can say it’s almost disappeared.”
Six more, on camera, in their own words
Every person here appears in our film, with a release on file. Results vary; the study section above describes the typical course.
The price while this lot is on the shelf
The price on this page is the price while this lot is on the shelf; when it changes, it changes here first. Shipping on the three and the six is on us. And the lot is the lot: when the shelf is empty, the page says so until the next two thousand arrive.
Take Joint Genesis the way the study did. One capsule with breakfast, then your walk, every day for six months. And if at the end of those six months your first three steps are the same as today, you have my word and the desk’s: your money back.
Two roads from here
Let me put the two roads side by side, because you are standing at the fork now.
The first road: nothing changes
The Joint Jello keeps thinning about one percent a year, which is what the journal measured. The stairs get slower. The garden gets shorter.
The floor with the grandchildren becomes a place you watch from the chair. And at the end of that road is the operation that a nine-year study of 4,500 people found changed less than they hoped. You become, in your own eyes, the person who needs a hand up.
See the card above: about one percent a year, from about age thirty.
The second road: you order the six today
For a week, nothing, and I have told you why. Then one morning in month two you reach the bottom of the stairs and realize you did not use the rail. In month three you kneel on the carpet because somebody small asked you to, and you get up without the hand.
In month four you do the whole garden in one afternoon and sleep like a child.
And by month six, the month the study’s curve was highest, something bigger has happened than any one of those.
You have stopped planning your days around your knees. You say yes to the trip. You take the stairs at the other end without looking at them first, and you walk the lake with your daughter on a Sunday and talk the whole way about something else.
One morning you stand up, take three steps, and realize you did not count them.
What happened to Sarah
After she had tried Joint Genesis herself, she called me, and she burst into tears over the phone, the way she had in my office. But these were not the same tears.
Her fingers were not locked together any more; she was baking and decorating wedding cakes again. She told me she had run up her stairs that morning, bouncing off each step, because her knees and hips were cushioned and moving again.
And she had a name for that morning. She called it her Independence Day, the day the thing that had been running her life was finally defeated, and I have used her word for it ever since.
The aisle that sold her glucosamine for two years still has it there today, at the same price, with no note. That is the thing I wanted you to see before you decide.
One last person, and then Ann, whose mornings started this letter.
★★★★★Lisa Medrano, 77Results vary; the study section above describes the typical course.
This really has been like a new beginning for me.
“I live alone after my husband passed away four years ago. I am fiercely independent but I have been very worried about my reduced mobility because of the pain in my hands, knees and hips. I was so frightened of falling over, or having to ask for help with simple household chores or groceries. This really has been like a new beginning for me.”
★★★★★Ann Jagodzinski, WisconsinResults vary; the study section above describes the typical course.
I now wake up with no pain in my knees and I feel less stiffness.
“I now wake up with no pain in my knees and I feel less stiffness.”
The choice as I see it
One road costs you nothing today and one percent a year. The other costs forty-nine dollars a bottle, your walk, and six months, with every dollar guaranteed if I am wrong.
Press the button and here is what happens. Most orders leave our warehouse within two business days, you get a tracking email the day yours leaves, and it arrives in five to seven business days anywhere in the United States, up to two weeks abroad.
The order page is run by ClickBank, so it will look a little different from this page, and the charge on your statement will say CLKBANK. That is normal, and it is the same company that handles your refund if you ever need one. Take the first capsule with breakfast, and walk to the mailbox.
Pick your pack, and join the BioDynamix family
Save $120
Best
value
value
$69 $49 per bottle
On subscription: $44.10 a bottle, $264.60 a course, 10 percent off every course
Add to cartTotal: $294
Shipping on us
180-day guarantee
Any reason, empty bottles and all.
Shipping on us
$69 per bottle
On subscription: $62.10 a bottle, $186.30 a course, 10 percent off every course
Add to cartTotal: $207
Shipping on us
180-day guarantee
Any reason, empty bottles and all.
$69 per bottle
On subscription: $62.10 a bottle, $62.10 a course, 10 percent off every course
Add to cartTotal: $69
Shipping at cost
180-day guarantee
Any reason, empty bottles and all.
Then stand up and take three steps.
Subscription, optional
- Your next course ships before this one runs out, so you never stand in week ten with an empty bottle.
- Ten percent off every course after this one, delivered every three or six months to match your pack.
- Nothing is charged today for it; the first charge is the day the next course ships, and you get an email a week before.
- Cancel any time with one call to 800-589-4191 or one click in that email. No questions.
The terms: the plan matches the pack you choose today; prices as shown on this page less ten percent; cancel before the reminder email’s date to skip a shipment; the 180-day guarantee covers every course.
Guaranteed for 180 days, any reason, empty bottles and all. Call 800-589-4191 and the desk refunds you.
Questions? Ask the desk, or call 800-589-4191; a person answers.
Still here? The questions our desk hears most
No problem. Here they are, in the order the desk hears them, ending with the one that matters most.
How is this different from what I have tried?
Everything you tried fed the cartilage or warmed the skin. Joint Genesis thickens the fluid the cartilage lives in, with the dose a six-month study used. The cards for that study are above.
How do I take it?
One capsule a day with water, with breakfast, then walk. A bottle is thirty capsules, a month.
How soon do most people notice anything?
In the study, month one was the first change and month six the best. Some people notice earlier. Give it the course.
Are there side effects, and who should talk to their doctor first?
Most people notice nothing but the walk. If you take a blood thinner, a daily medicine for your heart or your blood pressure, or you are pregnant or nursing, show your doctor the label first.
Can I take it with my other medicines?
Show the label to your doctor or pharmacist. That is the honest answer, and it takes two minutes.
When does it arrive, and what shows on my statement?
Most orders leave the warehouse within two business days and arrive in five to seven business days in the US, up to two weeks abroad. The charge on your statement shows as CLKBANK, the company that processes our orders; if you see that name and wonder, that is us.
How do I know I can trust the company?
Joint Genesis is made for BioDynamix in a US facility that follows current Good Manufacturing Practices and is inspected by the FDA, in small lots whose ingredients are tested for purity and potency before release, and a person answers our phone at 800-589-4191. BioDynamix is at 1301 Ridgeview Drive, McHenry, Illinois, the address on every bottle. The guarantee is the proof we mean it.
Is it in stock today?
The line under the pack table shows today’s count from our warehouse. When a lot runs out the page says so until the next one lands.
Is it sold anywhere else?
Yes. BioDynamix sells it on its own store and on Amazon. Wherever you buy it, it is the same bottle from the same lots, and the guarantee is the same.
How many bottles should I order?
The study ran six months, so six is the course. The bottles keep for two years in a cool, dry place, so nothing is wasted if you order the course and take your time.
What if I miss a day?
Take the next one with breakfast as usual. Do not double up.
What if it does not work for me?
Then it costs you nothing. One hundred and eighty days, any reason, empty bottles and all. I am asking you to decide nothing today except to start. Pick your pack below.
Seven more of our customers, with their photographs and their words as they sent them. Results vary; the study section above describes the typical course.
What came back
Hours in the garden“I had to limit myself to around ten minutes each time. Now the pain and stiffness has completely gone and I can spend hours at a time in my garden.”
The evening walks with her husband“I used to love evening walks with my husband but the pain became too much. Since trying this the discomfort has vanished and I can move freely.”
Sleeping through the night“My knees and hips hurt so bad they would keep me awake at night. I am now getting to sleep in minutes.”
Eighteen holes, and Barney walked every day“I had to stop playing golf with my friends and I was struggling even to walk my dog Barney for more than ten minutes. I am now playing a full eighteen holes every weekend without pain, walking Barney every day.”
Knitting for the grandchildren again“My wrists and fingers were so stiff and painful I was not able to do the same. Now they ache much less. I feel like I have got my purpose back.”
Dressing himself, and keeping his job“My wife was having to dress me. Thanks to Joint Genesis I can write and type without pain again, and I can dress myself with no discomfort at all.”
Tennis with his son“I was in so much pain I just couldn’t be the dad I wanted. I do genuinely feel like my knees have been reborn. I’m playing tennis again.”
Back at work“I work as a cleaner and I had begun to really struggle with my wrists and fingers, and also my knees. The pain has gone completely, and my joints feel twenty years younger.”
Knees like new again“I didn’t expect too much but I was impressed by the science and Dr Weis. I am so glad I decided to go for it. My knees feel like new again.”
The stairlift he never bought“It reached a point where I was looking into stairlifts. Now the pain has gone, the stiffness has gone, and the stairlift? Well, I sure don’t need it no more.”
The nights“I would feel the pain at night and sometimes in the mornings, and that’s definitely gone away. I feel a lot more confident that I can move around like I used to.”
Their words, from the letters and emails we keep on file. Results vary; the study section above describes the typical course.
Scientific references (15)
- The biggest test of glucosamine ever run: no better than a sugar pill. Clegg DO et al., New England Journal of Medicine, 2006; Sawitzke AD et al., Annals of the Rheumatic Diseases, 2010
- Common anti-inflammatories: heart-attack risk up by as much as half in the first week. Bally M et al., BMJ, 2017
- The old skeletons had the better knees. Wallace IJ, Lieberman DE et al., Proceedings of the National Academy of Sciences, 2017
- “The guardian of the joints”. St George’s, University of London (the film’s citation; the paper to confirm at sign-off)
- About one percent a year, from about age thirty. Arthritis Research and Therapy (the paper to confirm at sign-off)
- Farmers in their eighties with the joints of people half their age. Dr Toyosuke Komori’s records (the source to confirm at sign-off)
- Fourteen randomized, placebo-controlled, double-blind studies. The published Mobilee trials (Bioiberica); the list is in the claims file
- Eighty milligrams a day for six months: hyaluronan up tenfold, every month better than the last. The six-month Mobilee study (journal and year to confirm at sign-off)
- The pine bark’s compounds were found in the joint fluid itself. Jessberger S et al., BMC Complementary and Alternative Medicine, 2017
- Ninety days of boswellia: better comfort, better movement, less of the cartilage-eating enzyme. Sengupta K et al., Arthritis Research and Therapy, 2008
- Ginger: 63 in 100 reported less knee pain on standing, against 50 on the sugar pill. Altman RD, Marcussen KC, Arthritis and Rheumatism, 2001
- Five milligrams of piperine raised uptake of beta-carotene by about sixty percent. Badmaev V et al., 1999 and 2000
- Stronger around the knee, more stamina and power than placebo. Mediterranean Journal of Nutrition and Metabolism (year to confirm at sign-off)
- When they stopped, the improvements stopped, and began to reverse. The follow-up periods of the two Mobilee trials
- Nine years after a knee replacement: less change than people hoped. Ferket BS et al., BMJ, 2017
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Talk to your doctor before use if you are pregnant, nursing, taking medication or have a medical condition.